Lung Cancer Screening Implementation Guide Adding Smoking Cessation Estimated to Increase QALY and Lower Cost of Screening by 20 to 45% - Lung Cancer Screening Implementation Guide

Adding Smoking Cessation Estimated to Increase QALY and Lower Cost of Screening by 20 to 45%

Projected 15-year costs and quality-adjusted life years saved by lung cancer screening and treatment with and without smoking cessation using stage shifts from NY-ELCAP and NLST in authors' actuarial model.
	NY-ELCAP stage shift	NLST stage shift
Screening
Lung cancer	$27,824,282,242	$34,054,299,361
QALYs saved by screening and treatment	985,284	722,795
Cost per QALY saved	$28,240	$47,115
Screening + light smoking cessation intervention
Additional costs for cessation	$1,361,556,665	$1,361,556,665
Additional QALYs saved by cessation	273,566	273,566
Cost per QALY saved	$23,185	$35,545
Screening + intensive smoking cessation intervention
*A. NRT generic plus behavioral*
Additional costs for cessation	$3,212,191,737	$3,212,191,737
Additional QALYs saved by cessation	930,754	930,754
Cost per QALY saved	$16,198	$22,537
*B. Bupropion generic plus behavioral*
Additional costs for cessation	$4,088,822,965	$4,088,822,965
Additional QALYs saved by cessation	930,754	930,754
Cost per QALY saved	$16,656	$23,067
*C. Chantix plus behavioral*
Additional costs for cessation	$5,342,861,783	$5,342,861,783
Additional QALYs saved by cessation	930,754	930,754
Cost per QALY saved	$17,310	$23,826

NY-ELCAP, New York Early Lung Cancer Action Project; NLST, National Lung Screening Trial; QALY, quality-adjusted life year. doi:10.1371/journal.pone.0071379.t002

Villanti, Andrea & Jiang, Yiding & Abrams, David & Pyenson, Bruce. (2013). A Cost-Utility Analysis of Lung Cancer Screening and the Additional Benefits of Incorporating Smoking Cessation Interventions. PloS one. 8. e71379. 10.1371/journal.pone.0071379.